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E-Bulletin Cancer-Environnement

Ce bulletin de veille bibliographique sélectionne mensuellement des publications scientifiques identifiées dans le cadre de la veille du portail cancer- environnement.fr. La méthodologie de mise en œuvre de cette veille est présentée dans la fiche « Système de veille scientifique » : http://www.cancer-environnement.fr/334-Veille-scientifique.ce.aspx.

Publication du dernier E-Bulletin


Bulletin électronique de veille du portail Cancer-Environnement.fr

N°23 du 28/06/2017


Publications récentes

The information needs of adult cancer survivors across the cancer continuum: A scoping review.

Besoins d’information de l’adulte ayant survécu à un cancer dans les étapes de sa maladie : une revue exploratoire.

Fletcher et al., Patient Educ Couns. 2017 Mar

OBJECTIVE: To provide an updated synthesis of the literature that investigates the self-reported information needs of people diagnosed with cancer across the cancer continuum.

METHODS: We conducted a scoping review of the literature published from August 2003 to June 2015 and expanded an existing typology summarizing the information needs of people diagnosed with cancer.

RESULTS: The majority of the included studies (n=104) focused on questions relevant to the diagnosis/active treatment phase of the cancer continuum (52.9%) and thus the most frequently identified information needs related to this phase (33.4%). Information needs varied across the continuum and the results highlight the importance of recognising this fact.

CONCLUSION: People diagnosed with cancer experience discrete information needs at different points from diagnosis to survival. Much of the research conducted in this area has focused on their information needs during the diagnosis and treatment of cancer, and literature relating to information needs following completion of treatment is sparse.

PRACTICE IMPLICATIONS: Further research is needed to discern the specific nature of the treatment concerns and identify the information needs that survivors experience during recurrence of cancer, metastasis or changes in diagnosis, and the end of life phase of the cancer continuum.


Pesticide exposure and liver cancer: a review.

Exposition aux pesticides et cancer du foie : une revue de la littérature.

VoPham T et al., Cancer Causes Control. 2017 Mar

 PURPOSE:  To review the epidemiologic literature examining pesticide exposure and liver cancer incidence.

METHODS:  A search of the MEDLINE and Embase databases was conducted in October 2015. Eligibility criteria included examining hepatocellular carcinoma (HCC) or primary liver cancer, pesticides as an exposure of interest, and individual-level incidence. The review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

RESULTS:  Forty-eight papers were assessed for eligibility and 15 studies were included in the review. The majority of studies were conducted in China and Egypt (n = 8), used a case-control design (n = 14), and examined HCC (n = 14). Most studies showed no association between self-reported and/or occupational exposure to pesticides and liver cancer risk. Six studies demonstrated statistically significant positive associations, including three biomarker-based studies (two using pre-diagnostic sera) that reported higher serum levels of dichlorodiphenyltrichloroethane (DDT) were associated with increased HCC risk. Studies indirectly measuring pesticide exposure using self-reported exposure, occupation, job-exposure matrices, or geographic residence demonstrated inconsistent results. These studies were limited by exposure assessment methods, lack of confounder information, minimal case confirmation, selection bias, and/or over-adjustment.

CONCLUSIONS:  There is mixed evidence suggesting a possible association between specific pesticides and HCC risk, with the strongest evidence observed in biomarker-based studies. In particular, organochlorine pesticides, including DDT, may increase HCC risk. Future research should focus on improved pesticide exposure assessment methods, potentially incorporating multiple approaches including biomonitoring while considering the chemicals of interest, historical exposure to address latency periods, and examining specific chemicals and exposure pathways.

The association between the incidence of postmenopausal breast cancer and concentrations at street-level of nitrogen dioxide and ultrafine particles

L'association entre l'incidence du cancer du sein post-ménopausique et les niveaux de dioxyde d'azote et des particules ultrafines émises au niveau de la voie public

Goldberg MS et al., Environ Res. 2017 Jun

BACKGROUND:  There is scant information as to whether traffic-related air pollution is associated with the incidence of breast cancer. Nitrogen dioxide (NO2) and ultrafine particles (UFPs, <0.1µm), are two pollutants that capture intra-urban variations in traffic-related air pollution and may also be associated with incidence.

METHODS:  We conducted a population-based, case-control study of street-level concentrations of NO2 and UFPs and incident postmenopausal breast cancer in Montreal, Canada. Incident cases were identified between 2008 and 2011 from all but one hospital that treated breast cancer in the Montreal area. Population controls were identified from provincial electoral lists of Montreal residents and frequency-matched to cases using 5-year age groups. Concentrations of NO2 and UFPs were estimated using two separate land-use regression models. Exposures were assigned to residential locations at the time of recruitment, and we identified residential histories of women who had lived in these residences for 10 years or more. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models adjusting for individual-level and ecological covariates. We assessed the functional form of NO2 and UFP exposures using natural cubic splines.

RESULTS:  We found that the functional form of the response functions between incident postmenopausal breast cancer and concentrations of NO2 and UFPs were consistent with linearity. For NO2, we found increasing risks of breast cancer for all subjects combined and stronger associations when analyses were restricted to those women who had lived at their current address for 10 years or more. Specifically, the OR, adjusted for personal covariates, per increase in the interquartile range (IQR=3.75 ppb) of NO2 was 1.08 (95%CI: 0.92-1.27). For women living in their homes for 10 years or more, the adjusted OR was 1.17 (95%CI: 0.93-1.46; IQR=3.84 ppb); for those not living at that home 10 years before the study, it was 0.93 (95%CI: 0.64, 1.36; IQR=3.65 ppb). For UFPs, the ORs were lower than for NO2, with little evidence of association in any of the models or sub-analyses and little variability in the ORs (about 1.02 for an IQR of ~3500cm-3). On the other hand, we found higher ORs amongst cases with positive oestrogen and progesterone receptor status; namely for NO2, the OR was 1.13 (95%CI: 0.94-1.35) and for UFPs it was 1.05 (95%CI: 0.96-1.14).

CONCLUSIONS:  Our findings suggest that exposure to ambient NO2 and UFPs may increase the risk of incident postmenopausal breast cancer especially amongst cases with positive oestrogen and progesterone receptor status.

 Breast cancer and exposure to tobacco smoke during potential windows of susceptibility

 Cancer du sein et exposition à la fumée de tabac dans les potentielles fenêtres de susceptibilité

White AJ et al., Cancer Causes Control 2017 May

 PURPOSE:  An association between smoking and breast cancer is unresolved, although a higher risk from exposure during windows of susceptibility has been proposed. The objective of this prospective study was to evaluate the association between tobacco smoke and breast cancer with a focus on timing of exposure, especially during early life.

METHODS:  Sister study participants (n = 50,884) aged 35-74 were enrolled from 2003 to 2009. Women in the United States and Puerto Rico were eligible if they were breast cancer-free but had a sister with breast cancer. Participants completed questionnaires on smoking and environmental tobacco smoke (ETS) exposure. Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) for breast cancer risk.

RESULTS:  During follow-up (mean = 6.4 years), 1,843 invasive breast cancers were diagnosed. Neither active smoking nor adult ETS was associated with breast cancer risk. However, never smoking women exposed to ETS throughout their childhood had a 17% higher risk of breast cancer (95% CI 1.00-1.36) relative to those with no exposure. In utero ETS exposure was also associated with breast cancer (HR = 1.16, 95% CI 1.01-1.32) and the HR was most elevated for women born in earlier birth cohorts (<1940, HR = 1.44, 95% CI 1.02-2.02; 1940-1949, HR = 1.28, 95% CI 1.01-1.62).

CONCLUSION:  In utero ETS and ETS exposure during childhood and adolescence were associated with increased risk of breast cancer and associations varied by birth cohort.


Alcohol consumption and breast cancer risk by family history of breast cancer and folate intake in younger women

Consommation d'alcool et risque de cancer du sein chez les jeunes femmes avec antécédents familiaux de cancer du sein et apport en folates

Ja Kim H et al., Am J Epidemiol 2017 May

To evaluate the association between alcohol consumption and breast cancer risk in younger women, and by family history of breast cancer and folate intake, we prospectively followed 93,835 U.S. women aged 27-44 years with alcohol consumption data in 1991 in the Nurses' Health Study II. Alcohol and folate intake was measured by food frequency questionnaire repeated every 4 years. We documented 2,866 incident invasive breast cancer cases between 1991 and 2011. Alcohol consumption was not associated with breast cancer risk overall (multivariate hazard ratio = 1.07, 95% confidence interval: 0.94, 1.22 for ≥ 10 g/d intake vs. nondrinkers). When the association was stratified by family history and folate intake, a positive association between alcohol consumption and breast cancer was found among those with a family history and folate intake of < 400 μg/d (multivariate hazard ratio = 1.82; 95% confidence interval: 1.06, 3.12; P-trend = 0.08). Alcohol intake was not associated with breast cancer in other categories of family history and folate intake (P-interaction = 0.55). In conclusion, in this population of younger women, higher alcohol consumption was associated with increased risk of breast cancer among those with both family history of breast cancer and lower folate intake.

Attentes des ARS en matière de données de surveillance épidémiologique des cancers

Catelinois O. Santé publique France

L’objectif de cette enquête est de consolider la stratégie nationale et régionale de Santé publique France en matière de surveillance et de mise à disposition des indicateurs épidémiologiques sur les cancers. Ces indicateurs doivent directement contribuer au pilotage, à la coordination et à l’évaluation des politiques publiques concernant la prévention et la prise en charge des cancers.

Une enquête descriptive à caractère multicentrique a été réalisée par les Cire, en concertation avec la Direction des maladies non transmissibles et des traumatismes de Santé publiques France, auprès de 14 ARS. L’enquête a permis d’interroger différents interlocuteurs d’ARS, permettant de couvrir l’ensemble des champs de la santé liés aux domaines des cancers, notamment la prévention, le dépistage, la santé environnementale, les stratégies de santé ou encore l’offre de soins.

L’enquête montre les multiples attentes des ARS vis-à-vis des Cire et plus largement de Santé publique France pour disposer d’informations régionales et infrarégionales afin de conduire et d’évaluer leur politique de santé. Les ARS sont particulièrement intéressées par des données épidémiologiques sur les cancers pouvant faire l’objet de prévention ou de dépistage (ex : cancer du poumon, cancer du sein, cancer de la prostate ou cancer du sein). Pour Santé publique France, l’enjeu sera d’améliorer la valorisation des informations épidémiologiques sur les cancers à une échelle temporelle et géographique adaptée tout en poursuivant les travaux innovants réalisés dans un cadre partenarial avec Francim et les registres afin de mieux répondre aux attentes exprimées. Une attention particulière devra être portée sur la diffusion dans les régions des informations épidémiologiques sur les cancers, sur les nouvelles sources d’information comme le dossier communicant cancer et sur la poursuite des développements statistiques.


Actualités et lettres d’information des acteurs Santé Environnement

Région Rhône-Alpes :

Agence Régionale de Santé Auvergne- Rhône-Alpes

Atmo Auvergne-Rhône-Alpes


Lettre d’information de la recherche en santé Publique

National :

Agence nationale de sécurité sanitaire, de l’alimentation, de l’environnement et du travail

Santé Publique France

Institut National du Cancer

Institut national de recherche en sciences et technologies pour l’environnement et l’agriculture

de l’Lettre d’informationInstitut National de Recherche et de Sécurité pour la prévention des accidents du travail et des maladies professionnelles

Lettre d’information “Ademe et vous

La lettre de la Société Française de Santé Environnement

Société Française de Santé PubliqueBulletin Flash e-mail SFSP

Société Française de Médecine du Travail


Avec le soutien  de la Région Auvergne-Rhône-Alpes

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« La relecture et sélection des publications de ce bulletin électronique est réalisée par des membres du comité éditorial du portail cancer-environnement.fr avec la participation des professionnels de santé du Centre Léon Bérard et ses partenaires, sur la base de leur pertinence dans le champ ‘cancer, environnement et nutrition’. Dans la mesure où le contenu des sources et des informations recensées dans ce e-bulletin n’engagent que leurs auteurs, il appartient au lecteur d’en évaluer la qualité. »

 E-Bulletin réalisé par le Comité Editorial du portail http://www.cancer-environnement.fr/48-Qui-sommes-nous.ce.aspx




Mise à jour le 29 juin 2017

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